East 6.4 Module: Multi-Arm

This annual license fee is for a single designated desktop digital download license.

Requirements - Purchase of East Base

MULTIARM is an East module that offers the ability to plan, simulate, analyze, and communicate multi-arm fixed sample clinical trial designs. MULTIARM provides a wide variety of multiple testing procedures for the strong control of family-wise type-1 error rate when comparing multiple treatment arms to a control for Normal and Binomial endpoints.

East MULTIARM guides users through the complexities of multiplicity adjustment in order to construct reliable trials with multiple arms. A crucial regulatory requirement for multi-arm trials is establishing strong control of the family-wise error rate. East provides a variety of multiplicity adjustment measures to confirm strong control, along with advanced calculations that demonstrate a trial’s statistical power.

• Continuous endpoint: Difference of means
• Binary endpoint: Difference on proportions

Parametric Multiple Comparison Procedures:

• Dunnett’s single step
• Dunnett's step down
• Dunnett's step up

P-value based Multiple Comparison Procedures:

• Bonferroni
• Sidak
• Weighted Bonferroni
• Holm's step down
• Hochberg's step up
• Hommel's step up
• Fixed Sequence
• Fallback

View software license agreement here:

www.cytel.com/software-solutions/east/terms