East 6.4 Module: Escalate

This annual license fee is for a single designated desktop digital download license.

Requirements - Purchase of East Base

ESCALATE is an East module for the design, simulation, and monitoring of modern dose-escalation clinical trials. Evaluate and compare the operating characteristics of your designs under different assumptions about the dose-toxicity profile. Provide optimal dose recommendations for the next cohort of patients based on accumulating data. Clearly communicate critical information to clinicians to guide dosing decisions. Model-based dose-escalation methods in this module include the Continual Reassessment Method (mCRM; Goodman et al., 1995),  the Bayesian logistic regression model (BLRM; Neuenschwander et al., 2008), and the modified Toxicity Probability Interval (mTPI; Ji et al., 2010). 


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