This annual license fee is for a single designated desktop digital download license.
Requirements - Purchase of East Base Module
The European Medicines Agency (EMA) has qualified the Multiple Comparison Procedure – Modelling (MCP Mod) approach as an efficient statistical methodology for design and analysis of phase II dose finding studies under model uncertainty. East MCP Mod allows for the design and analysis of such studies for normal, binomial and count endpoints, with a variety of candidate models, dose selection criteria, and optimal allocations.
MCP Mod methodology is a combination of MCP (Multiple comparison procedures) and Mod (modeling) approaches (Bornkamp et al., 2009) for fitting a dose-response. This module allows you to design as well as analyze dose-response studies using MCP Mod.
Sample Size and Power Computation based on Optimal Allocation
East now offers users the ability to design dose-finding clinical trials using the MCP Mod methodology. Sample size and power computations can be done with user defined or optimized allocations.
Data Analysis using MCP Mod
East will accept raw subject data, summarized data or data with a covariance matrix for discrete and count data. In the case of continuous data, East only accepts raw data. East can perform multiple contrast tests to control Type I error, adjusting for the fact that multiple candidate dose-response models are being considered.
Continuous, Discrete and Count Endpoint