East 6.5 Module: Enrich

This annual license fee is for a single designated desktop digital download license.

Academic pricing.

Requirements - Purchase of East Base, Sequential and Survival Modules

East ENRICH supports the simulation of clinical trial designs with adaptation options for population enrichment, while strongly controlling type-1 error rate. It provides flexibility in defining the promising zone for sample size increase, and enrichment zone for subgroup selection.

Features - Population enrichment design for survival endpoint

East now offers users the ability to simulate a population enrichment design with a survival endpoint. This design starts out by enrolling subjects from a full population, which consists of a subpopulation of interest and its complement. East allows the user to perform an interim analysis and decide whether to continue enrolment in both subpopulations with or without sample size re-estimation, only continue enrolment from the subpopulation of interest, or terminate the trial for futility.

  Benefits

• Seamless phase 2/3 with Phase 2 objective to select the right patient population and Phase 3 to confirm the effect in the selected population
• Allows adaptation in sample size and patient population
• Mitigate risk of uncertainty around treatment effect and patient population
• Precision medicine to target the right treatment for the right patient population

   Availability

Survival Endpoint